![]() ![]() After characterization, the amount of paracetamol in the formulationwill be measured. After the solid dispersion formed, this formula is characterized using FTIR to determine the interactions between paracetamol and PEG 4000 as a sign of formed solid dispersion. ![]() To find the effect of the amount of PEG 4000 for the solubility enhancement, two formulas of solid dispersion are made with the ratio of 1:0.5 and 1:1. Paracetamol is dispersed in PEG 4000 as hydrophilic carrier with melting method. Enhancement of solubility can be achieved by formulation of solid dispersion. This property will affect its bioavailability. Abstract - Paracetamol is one of drugs which has low solubility property in aqueous medium.
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